There's a launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to decrease afferent suffering transmission and deliver analgesia. For that reason, prescription drugs like clonidine that target alpha-2 receptors can influence the transmission of discomfort. Relates to clonidine: oral pill, https://dmozbookmark.com/story19793226/onolidine-an-overview