And lastly, clonidine boosts neuraxial opioids and, together with fentanyl, interacts within an additive method, which might decrease the dose of each element by sixty% for postoperative analgesia. Significant Allergic Reactions. Clonidine may perhaps result in allergic reactions, which may be really serious. Halt taking clonidine and obtain assistance https://www.proleviate.com/post/the-new-pain-killer-conolidine