Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts with the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions, that... https://harryr531kry7.wikipowell.com/user