The altered IgG glycoforms activate innate immune cells, within a preclinical stage, promoting the transition to intestinal inflammation. Most current Evaluations & Assessment Improvements within the glycosylation of circulating IgG predict future Crohn’s illness onset Patients with Crohn’s disease display an altered serum IgG glycosylation signature that's detectable many years https://directivepublications.org/journal-of-immunology/